Due to Safari bugs, some audio formats may have occasional popping/cut off in playback. There is no specification of which audio formats are affected, but it seems to at least affect some FLAC files.
Media Session API is currently disabled in Webkit2Gtk, meaning viewing/management of playback from the desktop/MPRIS is not available. See https://bugs.webkit.org/show_bug.cgi?id=247527#c10 for more information.Binding to Rust to implement MPRIS support would be possible, if anyone would like to make a PR for that. ;)
Media streaming is not supported. This means that the entire file has to be loaded into memory before it can be played. This should not have noticeable performance impact unless playing very large tracks. See https://bugs.webkit.org/show_bug.cgi?id=146351#c5.